Galapagos to Acquire Drug Discovery Service Operations
of Discovery Partners International
Acquisition
positions BioFocus as top five player
worldwide in drug discovery services
Webcast
Conference Call Scheduled for 10:30 AM CET today
•
Galapagos will pay DPI €4.25 million ($5.4 million) in cash
• Four DPI research sites in US, Germany, and Switzerland
will add breadth and depth to Galapagos’ BioFocus division
• Transaction creates strong foothold for Galapagos in the
US
• Galapagos acquires additional capacity for strategic alliance
with GSK
• Acquired service activities are expected to add over €8
million ($10.2 million) in revenues to BioFocus DPI in second half
of 2006 and be cash flow accretive in 2007
San
Diego, California, USA, and Mechelen, Belgium, June 13, 2006; Discovery
Partners International, Inc., or DPI (Nasdaq: DPII), and Galapagos
NV (Euronext & LSE: GLPG), an integrated drug discovery company,
today announced that they have entered into a definitive purchase
agreement to transfer all of the drug discovery service operations
of DPI to Galapagos for €4.25 million ($5.4 million) in cash.
The acquisition includes the assets of all four of DPI’s drug
discovery services sites: San Diego and South San Francisco, USA,
Allschwill (Basel), Switzerland and Heidelberg, Germany as well
as DPI's Japanese sales office in Tokyo.
Under
the terms of the agreement, DPI will sell to Galapagos all of the
outstanding capital stock or equity interests of its direct subsidiaries
Discovery Partners International AG, ChemRx Advanced Technologies,
Inc., Xenometrix, Inc. and Discovery Partners International, L.L.C.,
along with certain contracts to be assigned by DPI to Galapagos
in connection with the transaction. The transaction is subject to
customary closing conditions and is expected to close in July 2006.
All
four of the current DPI sites will remain fully operational and
will be merged into BioFocus, the drug discovery services division
of Galapagos. As a smooth transition of the service business is
anticipated and planned for, current customers of DPI can expect
service levels at all sites to be fully maintained during this ownership
change. BioFocus will assume the scientific management of these
sites, including execution of all current service contracts, while
other operational functions will be managed directly by Galapagos.
The companies anticipate some downsizing of general and administrative
functions in the San Diego facility, related to the integration
of the various service organizations.
As
a result of the integration of the DPI activities within BioFocus
and to recognize the value and reputation of the DPI brand name
in the field of drug discovery services, BioFocus is changing its
name to BioFocus DPI.
"We
are extremely pleased that we will be able to add the excellent
drug discovery activities of DPI to our BioFocus division. We believe
that DPI’s capabilities will substantially strengthen our
technology, product offering and customer base. This acquisition
will position BioFocus DPI as a top five player worldwide in drug
discovery services and provides Galapagos with a strong presence
in the US," said Onno van de Stolpe, CEO of Galapagos. "We
will now have a global reach with operations in seven countries.
The combined group will be able to provide services ranging from
target identification to delivery of drug candidates. We believe
this positions the Company well for additional turnkey deals like
the alliance announced last week between Galapagos and GlaxoSmithKline.
With this acquisition, we also obtain additional capacity to accelerate
the program within this alliance. We look forward to servicing DPI
customers and would like to welcome them to the BioFocus DPI family."
"We
believe that, combined with the previously announced merger of Discovery
Partners International with Infinity Pharmaceuticals, Inc., the
sale of the drug discovery service operations of DPI to Galapagos
obtains an excellent result for our stockholders," said Michael
C. Venuti, Ph.D., Acting Chief Executive Officer, DPI. “As
we have previously discussed in our announcement of the pending
merger with Infinity, the sale of these operational assets is an
important component of that transaction. On closing of this asset
sale, we will have transferred the operations to Galapagos, a group
that already has a viable model for combining proprietary and contract
research on a worldwide basis. Concomitantly, we will have added
significantly to our cash position to help achieve a Net Cash balance
at the time of the closing of the merger with Infinity that is well
within our targeted $70-75 million range to set the exchange ratio
to be used in the Infinity merger. We believe the combination of
these two strategic transactions provides DPI’s current shareholders
with an excellent opportunity to achieve value through ownership
in a marketable security based on Infinity’s advanced drug
discovery and development capabilities, and tangible product candidate
portfolio,” concluded Venuti.
Rationale
and strategy of acquisition by Galapagos
Galapagos
will acquire the operational activities of DPI as part of its strategy
to become a worldwide leader in drug discovery services, ranging
from target discovery all the way through to the delivery of compounds
with clinical proof of concept. The Company combines this services
activity (BioFocus DPI) with internal drug discovery programs in
bone and joint disease, where it aims to bring its own candidate
drugs into the clinic. This hybrid business model enables Galapagos
to leverage the broad drug discovery expertise of BioFocus DPI to
generate revenues, while building a pipeline of candidate drugs
for future partnering at various stages during their development
phase. This business strategy validates Galapagos’ technology
and reduces the capital needed to develop its own candidate drugs.
The four operating companies of DPI strengthen and broaden the BioFocus
product offering in the following ways:
• the Swiss operation has world class hit finding activities
(assay development and high-throughput screening), with access to
over 600,000 synthetic chemical compounds, greatly expanding the
capabilities and collections of BioFocus;
• the German operation has an extensive collection of natural
compounds originating from Actinomycetes and fungi - with over 140,000
isolated sub-fractions, over 75,000 purified extracts and more than
1,000 isolated compounds, this platform complements the current
BioFocus expertise in synthetic chemistry;
• the San Diego operation has a lead optimization platform
and chemical library development capabilities which provide additional
capacity for BioFocus contracts. This site will operate as Galapagos’
North America headquarters;
• the San Francisco operation is a compound management facility
established through a multi-year contract with the National Institutes
of Health, one of the world’s foremost medical research organizations.
This operation maintains a repository of small molecules to manage
and provide chemical compounds to multiple NIH screening centers.
With this compound management facility, BioFocus further expands
its service offering by marketing this infrastructure and capability
to pharma and biotech customers;
• The Tokyo sales office provides a physical presence for
BioFocus in the large Japanese market.
Galapagos will operate these companies through its service division
BioFocus DPI. There are approximately 100 people employed at the
acquired sites, bringing the total Galapagos headcount to over 320
staff, including 144 PhDs, in seven countries.
With the San Diego and San Francisco operations, Galapagos also
obtains a firm US presence in addition to its existing BioFocus
sales office in Boston opened in November 2005. Galapagos will use
these operations to increase its visibility and market share in
the US drug discovery market.
Galapagos anticipates that DPI operations will contribute more than
€8 million ($10.2 million) in external revenues to BioFocus
DPI for the six months remaining in 2006. Major 2006 customers for
these operations include Actelion, Allergan, Biovitrum, GSK, Mitsubishi
Pharma, NIH, Novartis and Ono.
The acquisition of DPI’s operational activities fits well
within the Galapagos and BioFocus strategy to partner with pharmaceutical
and biotechnology companies in turnkey target to candidate drug
collaborations, as it strengthens BioFocus’ breadth of technologies
and services and provides the capacity necessary to deliver results
in such alliances. The additional capacity obtained through the
acquisition will be used partly to accommodate the expansion of
activities in the Galapagos osteoarthritis program under the alliance
with GSK announced last week. In addition, DPI provides the capacity
BioFocus was looking for to fulfill its expanding order book.
Webcast
conference call details
Dr.
Venuti, Mr. van de Stolpe and CFO Galapagos Mr. Smith will host
a joint conference call discussing the transaction today at 10:30
AM CET. To participate in the call, dial +32 2290 1608 ten minutes
in advance of the call. A live webcast of the conference call can
be accessed on the DPI and Galapagos websites at www.discoverypartners.com
and www.glpg.com, respectively. An archived version of the webcast
will be available following the conference call and archived on
both companies’ websites.
About
Galapagos NV
Galapagos is a publicly traded, genomics-based drug discovery company
(Euronext Brussels, GLPG; Euronext Amsterdam, GLPGA, London AiM:
GLPG) that has drug discovery programs based on proprietary, novel
targets in bone and joint diseases - osteoarthritis, osteoporosis
and rheumatoid arthritis. Galapagos offers a full suite of target-to-drug
discovery products and services to pharmaceutical and biotech companies
through its division BioFocus, encompassing target discovery and
validation, and drug discovery services through to delivery of pre-clinical
candidates. In addition, BioFocus provides adenoviral reagents for
rapid identification and validation of novel drug targets and compound
libraries for screening. Up to closure of this transaction, Galapagos
employs more than 220 people, including 80 PhDs, and occupies facilities
in Mechelen, Belgium, Saffron Walden, UK and Leiden, The Netherlands.
Partners of Galapagos and BioFocus include Amgen, AstraZeneca, Boehringer
Ingelheim, Celgene, GlaxoSmithKline, Idenix, Novartis, Organon,
Roche, Serono, Vertex, and Wyeth. More information about Galapagos
and BioFocus can be found at www.glpg.com.
About Discovery Partners International, Inc.
Up
to the closure of this transaction, Discovery Partners International,
Inc., a small molecule and natural product-based drug discovery
company, offers collaborations and services complementing the internal
capabilities of pharmaceutical and biopharmaceutical companies.
DPI has actively contributed to dozens of drug discovery collaborations.
DPI is headquartered in San Diego, California, with operations in
the United States and Europe. More information about Discovery Partners
International can be found at www.discoverypartners.com.
Forward
looking statements
This
release contains certain forward-looking statements that involve
risks and uncertainties that could cause actual results to be materially
different from historical results or from any future results expressed
or implied by such forward-looking statements. You are urged to
consider statements that include the words "may," "will,"
"would," "could," "should," "believes,"
"estimates," "projects," "potential,"
"expects," "plans," "anticipates,"
"intends," "continues," "forecast,"
"designed," "goal," or the negative of those
words or other comparable words to be uncertain and forward-looking.
Any forward-looking statements are made pursuant to Section 27A
of the Securities Act of 1933, as amended, and Section 21E of the
Securities Exchange Act of 1934, as amended. Any forward-looking
statements made by DPI or Galapagos speak only as of the date made.
DPI and Galapagos undertake no obligation to publicly update any
forward-looking statements, whether as a result of new information,
future events or otherwise.
Such
forward-looking statements include statements regarding the proposed
transaction between DPI and Galapagos and the timing for its closing,
the contribution of the assets to be acquired to BioFocus's revenues
in the second half of 2006 and cash flow in 2007, the integration
of those assets into Galapagos's existing operations, including
with respect to maintaining service levels for current DPI customers,
the anticipated downsizing of DPI's general and administrative function
in San Diego, the benefits of the proposed transaction to Galapagos's
existing operations, including with respect to its technology, product
offerings, customer base, and market and competitive positions,
Galapagos's rationale and strategy for the proposed transaction,
and the benefits of the proposed transaction to DPI, including for
its stockholders and with respect to the exchange ratio to be used
in DPI's merger with Infinity and DPI's ability to consummate that
transaction. Factors that may cause actual results to differ materially
include the risk that DPI and Galapagos may not be able to complete
the proposed transaction, the risk that the assets being acquired
may not be integrated as effectively into Galapagos as expected
or otherwise provide Galapagos with their expected benefits, the
risk that the proposed transaction together with DPI's proposed
merger with Infinity will not provide their expected benefits to
DPI's stockholders and that DPI's Net Cash at closing of the Infinity
merger will be lower than currently anticipated, and risks and other
uncertainties more fully described in DPI's annual report on Form
10-K for the year ended December 31, 2005 and quarterly report on
Form 10-Q for the quarter ended March 31, 2006, as filed with the
Securities and Exchange Commission and DPI's other SEC reports.
Additional
information about the DPI-Infinity merger and where to find it
In
connection with the proposed merger between DPI and Infinity described
herein, DPI filed a registration statement on Form S-4 on May 24,
2006 with the SEC, that contains a proxy statement/prospectus. Investors
and security holders of DPI and Infinity are urged to read the proxy
statement/prospectus (including any amendments or supplements to
the proxy statement/prospectus) regarding the proposed merger because
it contains important information about DPI, Infinity and the proposed
merger. Securityholders will be able to obtain a copy of the proxy
statement/prospectus, as well as other filings containing information
about DPI and Infinity, without charge, at the SEC’s Internet
site (http://www.sec.gov). Copies of the proxy statement/prospectus
can also be obtained, without charge, by directing a request to
Discovery Partners International, Inc., 9640 Towne Centre Drive,
San Diego, CA 92121, Attention: Investor Relations, Telephone: (858)
455-8600.
Participants
in the solicitation
DPI and its directors and executive officers and Infinity and its
directors and executive officers may be deemed to be participants
in the solicitation of proxies from the stockholders of DPI in connection
with the proposed merger of DPI with Infinity. Information regarding
the special interests of these directors and executive officers
in the merger transaction is included in the proxy statement/prospectus
referred to above. Additional information regarding the directors
and executive officers of DPI is also included in DPI’s proxy
statement for its 2006 Annual Meeting of Stockholders, which was
filed with the SEC on April 6, 2006. This document is available
free of charge at the SEC’s web site (www.sec.gov) and from
Investor Relations at DPI at the address described above.
CONTACTS:
For
Discovery Partners:
Michael C. Venuti, Ph.D.
Acting CEO
Tel: +1 858 455 8600
ir@discoverypartners.com
For
Galapagos NV:
Onno van de Stolpe
CEO
Tel: +31 6 290 980 28
ir@glpg.com
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